Module 8 Article Review: Hybridization

Kumar, Herrmann and Tsogoeva (1) undertook a study to explore how structural hybridization can be adopted using the facile approach in developing new drugs. Currently, the structural hybridization of clinically and preclinical is perceived as a new method, which can be useful in the production of efficient and safe drugs for most viral infections, cancer, and microbial infections. In order to address the inherent problems associated with most contemporary drugs, a strategic approach, which uses “drug-drug” methods, has been developed. Thus, the researchers have conducted an extensive review of existing literature that uses hybrid design, which focuses on linker architecture in the formulation of new drugs. The analysis results indicate that the hybridization design attained a high efficacy via selective drug delivery in the designated area. There were notable improvements or progress made in recent decades in respect to the alleviation of toxicity, bioavailability and reducing drug resistance.

Much of the literature provided by the researchers are based on subjective reasoning guided by pre-existing information. To ease the authenticity and validity of their findings, the researcher ought to undertake a large-scale study, which incorporates collecting data and chemical evidence directly from the source (laboratory) to make suitable conclusions. Essentially, adopting a case-study based approach will enable researchers to pre-test and post-test hybrid designs while focusing on linker architecture to measure the effectiveness of the newly developed hybrid drugs.

Nevertheless, the research conducted by Kumar, Herrmann and Tsogoeva (nd) has been instrumental in providing the latest literature in structural hybridization of new drugs, which can counter medical challenges associated with the 21st century. Furthermore, future researchers can use the research as a reference point.

Bibliography

Kumar, Halmuthur M. Sampath, Lars Herrmann, and Svetlana B. Tsogoeva. “Structural hybridization as a facile approach to new drug candidates.” Bioorganic & Medicinal Chemistry Letters (2020): 127514.